abstract：:Fifty of sixty original study subjects were assessed via two questionnaires and urinalysis tests between six months and one year following completion of the experimental program. Results indicate a high rate of retention in methadone/methadyl acetate treatment, and point to the need for positive social context, satisf...

journal_title：Drug and alcohol dependence

authors： Charuvastra VC,Panell J,Ling W,Ouren J

更新日期：1980-11-01 00:00:00

abstract：:Serum alcohol dehydrogenase (ADH) activity in some individuals contains a fraction that is not inhibited by pyrazole. This might be due to the presence in those sera of pi-ADH, a unique isoenzyme found recently in human liver, and which, according to one hypothesis, could be co-responsible for the development of alcoh...

journal_title：Drug and alcohol dependence

authors： Skurský L,Khayrollah A

更新日期：1980-09-01 00:00:00

abstract：:The literature on opium addiction in Asia reveals widely different sex ratios. Analysis of these reports indicates that community surveys provide the most reliable and valid ratios. Surveys in psychiatric hospitals appear to overreport women, while case registers and surveys in addiction treatment facilities, vends an...

journal_title：Drug and alcohol dependence

authors： Westermeyer J

更新日期：1980-09-01 00:00:00

abstract：:The drug habits for 78 confirmed opiate addicts were studied on eight scales from the Process Association Test of Addiction (PATA) for many drug names. Through cluster analysis eight stages of addiction were defined: "to be clean", "to learn about drugs", "to hustle", "to chip" (also "to be high"), to be psychological...

journal_title：Drug and alcohol dependence

authors： Haertzen CA,Ross FE

更新日期：1980-06-01 00:00:00

abstract：:A representative sampling of the secondary school population of two states of Malaysia (sample size 16166) indicated that 11% of students had had experience of drug use. Use of a single drug was the common pattern, with cannabis reported most often by older students, and sedatives most often by younger students. A qua...

journal_title：Drug and alcohol dependence

authors： Spencer C,Navaratnam V

更新日期：1980-05-01 00:00:00

abstract：:Alcohol increases libido, inhibits sexual physiological responses and adversely affects reproductive processes in men and women. The mechanisms that underlie these effects are examined and the implications of these effects are discussed. ...

journal_title：Drug and alcohol dependence

authors： Abel EL

更新日期：1980-05-01 00:00:00

abstract：:Drug usage patterns among patients admitted to a Swedish clinic specialized in the treatment of drug dependence have undergone significant changes during the last fifteen years. During this period there has been a decline in amphetamine taking and a rise in opiate abuse. Yearly cohorts of drug abusers were subjected t...

journal_title：Drug and alcohol dependence

authors： Frykholm B

更新日期：1980-02-01 00:00:00

abstract：:A methadone withdrawal programme (MWP) and a behaviour therapy programme (BTP) were compared in terms of their effectiveness to prevent relapse of heroin addicts after methadone treatment. The BTP incorporated systematic desensitization to effect a decrease in levels of fear of both physical and environmental withdraw...

journal_title：Drug and alcohol dependence

authors： Hollonds GB,Oei TP,Turecek LR

更新日期：1980-02-01 00:00:00

abstract：:One hundred and seventy-nine patients who were dependent on street narcotics were inducted into LAAM. Ninety-two were inducted using a slow schedule: 20, 20, 30, 30, 40, 40, 50, 50, 60, 60, 70, 70, 75 mg on successive clinic visits (Mon., Wed., Fri.). Only 23% of the patients followed this schedule to 50 mg; 55% reque...

journal_title：Drug and alcohol dependence

authors： Judson BA,Goldstein A

更新日期：1979-11-01 00:00:00

abstract：:Fifteen psychosocial characteristics of 300 male and 90 female heroin addicts admitted for inpatient detoxification, ambulatory detoxification, and methadone maintenance within the same multiphasic drug-abuse program were compared to determine whether or not their characteristics differentiated those seeking each type...

journal_title：Drug and alcohol dependence

authors： Steer RA

更新日期：1979-09-01 00:00:00

abstract：:The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these recept...

journal_title：Drug and alcohol dependence

authors： Hoffman PL,Tabakoff B

更新日期：1979-05-01 00:00:00

abstract：:This paper aims to outline some of the caveats inherent in studies on first and second messengers in the central nervous system as related to tolerance and dependence. Analysis of systems based on measures of first and second messengers may be an over-simplification, since the actual molecular consequences of neurotra...

journal_title：Drug and alcohol dependence

authors： Siggins GR

更新日期：1979-05-01 00:00:00

abstract：:A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...

journal_title：Drug and alcohol dependence

authors： Hunt WA,Majchrowicz E

更新日期：1979-05-01 00:00:00

abstract：:Synaptosomal plasma membrane (SPM), like other plasma membranes, is composed of lipids and proteins and appears to conform to the "fluid mosaic" model proposed by Singer and Nicolson. SPM components show a marked asymmetry with respect to their inside-outside distribution, with the majority of proteins being external....

journal_title：Drug and alcohol dependence

authors： Smith AP,Loh HH

更新日期：1979-01-01 00:00:00

abstract：:Product moment correlations were calculated between 17 psychosocial characteristics of 216 heroin addicts and their lengths of stay for first and second admissions to the dame methadone maintenance program. None of the variables which were related to retention during the first admission was associated with retention d...

journal_title：Drug and alcohol dependence

authors： Steer RA,Kotzker E

更新日期：1978-11-01 00:00:00

abstract：:To determine whether differences in life styles and patterns of drug use may help to account for willingness to try heroin and/or likelihood of becoming addicted, personal history interviews were conducted with 15 young heroin addict, 15 experimenters who used the drug but did not become addicts, and 15 nonusers who n...

journal_title：Drug and alcohol dependence

authors： Crawford GA

更新日期：1978-05-01 00:00:00

abstract：:Cerebral spinal fluid (CSF) levels of methadone were measured in nine methadone maintenance patients requiring lumbar punctures for medical or surgical treatment. Concurrent serum methadone levels were also determined. The CSF concentration of methadone in all cases was a fraction of the corresponding serum level--ran...

journal_title：Drug and alcohol dependence

authors： Rubenstein RB,Kreek MJ,Mbawa N,Wolff WI,Korn R,Gutjahr CL

更新日期：1978-03-01 00:00:00

abstract：:Infant rats, treated intracisternally with 6-hydroxydopamine or 5,7-dihydroxytryptamine, alone or in combination with desmethylimipramine or pargyline, at 5 to 7 days of age, had significant specific depletions of brain norepinephrine, dopamine, both of these amines, or serotonin at 2.5 months of age. Despite apparent...

journal_title：Drug and alcohol dependence

authors： Frye GD,Ellis FW

更新日期：1977-09-01 00:00:00

abstract：:The oral administration of single doses (0.5-6.0 g/kg) of ethanol to rats, shortly before injecting them with a large dose (3.0 mg base/kg) of epinephrine subcutaneously, significantly reduced the severity of the myocardial damage produced by the epinephrine. The larger the dose of ethanol, the greater was the protect...

journal_title：Drug and alcohol dependence

authors： Mallov S,Gilmour RF

更新日期：1977-09-01 00:00:00

abstract：:Adult female Sprague-Dawley rats were prepared with chronic intravenous cannulas and cortical and muscle electrodes for recording electroencephalograms and electromyograms, respectively. They were made physically dependent on morphine by automatic intravenous injections and then trained to lever press in order to self...

journal_title：Drug and alcohol dependence

authors： Young GA,Moreton JE,Meltzer LT,Khazan N

更新日期：1977-03-01 00:00:00

abstract：:The pre-treatment social stability score (combined economic-familial-residential scales), indicating whether the patients were comparatively integrated or disintegrated socially, was found to be of greater prognostic value regarding post-treatment drinking than was information about whether they received full, part or...

journal_title：Drug and alcohol dependence

authors： Williams RJ

更新日期：1977-03-01 00:00:00

abstract：:Position preference, i.e., the tendency to drink from onelocation rather than the other, was found to be relatively unimportant in determining the drinking behavior of rats presented with a choice between water and a 7% (v/v) ethanol solution in typical two-bottle choice situations. It accounted for essentially none o...

journal_title：Drug and alcohol dependence

authors： Sinclair JD

更新日期：1976-06-01 00:00:00

abstract：:A review of morbidity and mortality studies bearing on the hazards to physical health of chronic heavy alchol use indicates that such use carries a risk of premature death greatly exceeding normal expectancy. While the life style typical of many heavy drinker contributes to this risk, the effects of alcohol per se acc...

journal_title：Drug and alcohol dependence

authors： Schmidt W,Popham RE

更新日期：1975-09-01 00:00:00